Role of SATB2 and p16 expression and histomorphological features in the diagno-sis and differential diagnosis of atypical polypoidal adenomyoma
10.13315/j.cnki.cjcep.2025.04.008
- VernacularTitle:SATB2和p16表达以及组织形态学特征在非典型息肉样腺肌瘤诊断中的价值
- Author:
Wengeng WANG
1
;
Ming LI
;
Weigen ZHOU
;
Qiaohui ZHANG
;
Ping CHENG
;
Hongman DOU
Author Information
1. 安徽中医药大学第一附属医院病理科,合肥 230031
- Publication Type:Journal Article
- Keywords:
atypical polypoidal adenomyoma;
endometrioid carcinoma;
myometrial infiltrating;
endometrial polyps;
in-terstitial fibrotic;
SATB2;
p16
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(4):464-468,473
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the role of combined immunohistochemical expression of SATB2 and p16 and pathological histomorphological features in the diagnosis and differential diagnosis of atypical polypoid adenomyoma(APAM),myometrial infiltrating endometrioid carcinoma(MIEC)and interstitial fibrotic endometrial polyps(IFEP).Methods A total of 32 cases of APAM,20 cases of MIEC and 25 cases of IFEP were collected.The expression of SATB2 and p16 in the stromal cells of the three groups of cases was detected by immunohistochemical EnVision two-step method.Four morphological features were evaluated in the three groups:complex glandular structure,squamous and mulberry metaplasia,fibromuscular stroma and cellular atypia.Results The expression of SATB2 in the stroma of APAM(31/32)was significantly higher than that of MIEC(1/20)and IFEP(0/25),and the difference was statisti-cally significant.The expression of p16 in APAM(32/32)stroma was significantly higher than that in MIEC(3/20),and the difference was statistically significant,while compared with IFEP(21/25),the difference was not statistically significant.Histomorphological characteristics:compared with the MIEC group,APAM had obvious squamous and mul-berry metaplasia(APAM group 31/32,MIEC group 4/20),and the difference was statistically significant;However,there was no statistically significant difference between the two groups in terms of complex glandular structure(APAM group 22/32,MIEC group 20/20),fibromuscular stroma(APAM group 32/32,MIEC group 20/20),and cellular at-ypia(APAM group 32/32,MIEC group 20/20).Compared with the IFEP group,APAM had typical complex glandu-lar structure(APAM group 20/32,IFEP group 0/25),squamous and mulberry metaplasia(APAM group 32/32,IF-EP group 2/25),and cellular atypia(APAM group 32/32,IFEP group 0/25),and the difference was statistically sig-nificant.However,there was no statistically significant difference in fibromuscular stroma(APAM group 32/32,IFEP group 25/25)between the two groups.Conclusion The combined immunohistochemical analysis of SATB2 and p16 and histomorphological features is helpful for the diagnosis of APAM and the differential diagnosis of MIEC and IFEP.
