Clinical effects of Wenzhong Lidan Decoction combined with conventional treatment on patients with chronic cholecystitis due to Dampness-Heat of Liver and Gallbladder
10.3969/j.issn.1001-1528.2025.10.014
- VernacularTitle:温中利胆汤联合常规治疗对肝胆湿热证慢性胆囊炎患者的临床疗效
- Author:
Ming ZHAO
1
;
Lei TAI
;
Zhen-fang WANG
Author Information
1. 山东青岛中西医结合医院普外科,山东青岛 266002
- Publication Type:Journal Article
- Keywords:
Wenzhong Lidan Decoction;
conventional treatment;
chronic cholecystitis;
Dampness-Heat of Liver and Gallbladder;
immune functions;
gallbladder functions
- From:
Chinese Traditional Patent Medicine
2025;47(10):3269-3273
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of Wenzhong Lidan Decoction combined with conventional treatment on patients with chronic cholecystitis due to Dampness-Heat of Liver and Gallbladder.METHODS One hundred and eighty-six patients were randomly assigned into control group(93 cases)for 4-week administration of conventional treatment,and observation group(93 cases)for 4-week administration of both Wenzhong Lidan Decoction and conventional treatment.The changes in clinical effects,TCM syndrome scores,gallbladder function indices(thickness of gallbladder wall,contraction rate of gallbladder),gastrointestinal hormone(SS,VIP,MTL),immune function indices(IgM,IgA),chemokines(IP-10,MCP-1)and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed increased contraction rate of gallbladder and MTL(P＜0.05),and decreased TCM syndrome scores,thickness of gallbladder wall,SS,VIP,immune function indices and chemokines(P＜0.05),especially for the observation group(P＜0.05).No serious adverse reactions were observable in the two groups.CONCLUSION For the patients with chronic cholecystitis due to Dampness-Heat of Liver and Gallbladder,Wenzhong Lidan Decoction combined with conventional treatment can safely and effectively improve gallbladder and immune functions,reduce inflammatory response and regulate gastrointestinal hormones.
