Clinical effects of Qijing Buzhong Yishen Decoction on patients with diabetic nephropathy due to Spleen-Kidney Qi Deficiency and Blood Stasis Obstructing Collaterals
10.3969/j.issn.1001-1528.2025.10.013
- VernacularTitle:芪精补中益肾汤对脾肾气虚兼血瘀络痹证糖尿病肾病患者的临床疗效
- Author:
Hao-yu YUAN
1
;
Zi-cheng YE
;
Wen-kai XU
;
Sai-mei LI
Author Information
1. 云南中医药大学第一临床医学院,云南 昆明 650000
- Publication Type:Journal Article
- Keywords:
Qijing Buzhong Yishen Decoction;
conventional treatment;
diabetic nephropathy;
Spleen-Kidney Qi Deficiency;
Blood Stasis Obstructing Collaterals;
renal functions
- From:
Chinese Traditional Patent Medicine
2025;47(10):3264-3269
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of Qijing Buzhong Yishen Decoction on patients with diabetic nephropathy due to Spleen-Kidney Qi Deficiency and Blood Stasis Obstructing Collaterals.METHODS One hundred and two patients were randomly assigned into control group(51 cases)for 3-month intervention of conventional treatment,and observation group(51 cases)for 3-month intervention of both Qijing Buzhong Yishen Decoction and conventional treatment.The changes in clinical effects,blood glucose indices(fasting blood glucose,2 h postprandial blood glucose,HbA1c,TIR),blood lipid indices(TC,TG,LDL-C),renal function indices(UACR,eGFR,24 h urinary albumin excretion rate,sustained urinary albumin excretion rate),inflammatory factors(IL-6,hs-CRP,TNF-α),TCM syndrome scores and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased fasting blood glucose,2 h postprandial blood glucose,HbA1c,UACR,24 h urinary albumin excretion rate,sustained urinary albumin excretion rate,inflammatory factors,TCM syndrome scores(P＜0.05),and increased TIR,eGFR(P＜0.05),especially for the observation group(P＜0.05).No serious adverse reactions were observable in the two groups.CONCLUSION For the patients with diabetic nephropathy due to Spleen-Kidney Qi Deficiency and Blood Stasis Obstructing Collaterals,Qijing Buzhong Yishen Decoction can safely and effectively regulate the blood sugar levels,and improve renal functions.
