Correlation between Gleason grade and free prostate-specific antigen,serum ferritin and uric acid levels in patients with prostate cancer
10.13263/j.cnki.nja.2025.10.003
- VernacularTitle:前列腺癌患者游离前列腺特异性抗原、血清铁蛋白及血尿酸水平与Gleason分级相关性
- Author:
Haocheng ZHANG
1
;
Meimei TAO
;
Jiong ZHANG
;
Yuhang QIAN
;
Chunmei LIAO
;
Peng WANG
;
Genqiang LANG
;
Lin LI
;
Xiaojun DENG
Author Information
1. 上海大学附属四一一医院泌尿外科,上海 200081
- Publication Type:Journal Article
- Keywords:
prostate cancer;
free prostate-specific antigen;
serum ferritin;
blood uric acid;
Gleason grading
- From:
National Journal of Andrology
2025;31(10):881-884
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the correlation between free prostate specific antigen(fPSA),serum ferritin(SF),blood uric acid(SUA)levels and Gleason grading in patients with prostate cancer(PCa).Methods The clinical data of 61 patients with prostate biopsy treated in 411 Hospital of Shanghai University from January to December of 2023 were retrospectively analyzed.According to the results of puncture,the patients were divided into benign prostatic hyperpla-sia(BPH)group(31 cases)and PCa group(30 cases).The levels of fPSA,SF and SUA in patients and Gleason grade in biopsy cases were analyzed.The correlation between fPSA,SF and SUA levels and Gleason grade was analyzed by the method of Spearman.And the diagnostic efficacy of fPSA,SF and SUA levels on PCa was analyzed by receiver operating characteristic curve(ROC).Results The levels of fPSA,SF and SUA in PCa group were significantly higher than those in BPH group(P＜0.05).There were statistically significant differences in levels of fPSA SF and SUA in PCA patients with different Gleason grades(P＜0.05).With the specificity reaching 96.08％and sensitivity reaching 94.35％,the ar-ea under the curve(AUC)of the combined fPSA,SF and SUA levels in the diagnosis of PCa was 0.982,which was higher than that of the single fPSA,SF and SUA levels(P＜0.05).SF and SUA levels in PCa patients were positively correlated with Gleason grade(P＜0.05),while fPSA levels were not correlated with Gleason grade(P＞0.05).Conclusion The levels of SF and SUA in PCa patients are positively correlated with Gleason grade,which can be used as an important index to predict Gleason grade in PCa patients.
