The evaluation value of serum TRPV1,TIMP4 and TGF-β1 levels in predicting recurrence of benign paroxysmal positional vertigo
- VernacularTitle:血清TRPV1、TIMP4、TGF-β1水平对良性阵发性位置性眩晕复发的预测价值
- Author:
Lao HU
1
;
Cheng ZHANG
1
;
Zhijun HU
1
Author Information
- Publication Type:Journal Article
- Keywords: vertigo; TRPV cation channels; matrix metalloproteinase inhibitors; transforming growth factor beta1; recurrence
- From: Tianjin Medical Journal 2025;53(3):267-271
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the predictive value of serum levels of capsaicin receptor 1(TRPV1),matrix metalloproteinase inhibitor 4(TIMP4)and transforming growth factor beta 1(TGF-β1)for disease recurrence in patients with benign paroxysmal positional vertigo(BPPV).Methods A total of 326 BPPV patients were selected and used as the BPPV group,and 357 healthy individuals who underwent physical examinations during the same period were selected and used as the control group.According to the recurrence status of BPPV patients after 1 year of reduction treatment,patients were divided into the non recurrence group(264 cases)and the recurrence group(62 cases).Enzyme linked immunosorbent assay was used to detect serum levels of TRPV1,TIMP4 and TGF-β1 in patients.Multivariate Logistic regression analysis was performed to analyze influencing factors of recurrence in BPPV patients.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of TRPV1,TIMP4,and TGF-1 levels for recurrence in BPPV patients.Results TRPV1 and TIMP4 were lower in the BPPV group than those in the control group,while TGF-β1 was higher than that in the control group(P＜0.05).The TGF-β1 score in the recurrence group were higher than those in the non recurrence group,while TRPV1 and TIMP4 were lower than those in the non recurrence group(P＜0.05).Serum TRPV1 and TIMP4 levels were lower in the recurrence group than those of the non recurrence group,and TGF-1 levels were higher in the recurrence group than those of the non recurrence group(P＜0.05).The decreased serum levels of TRPV1 and TIMP4 were risk factors for recurrence in BPPV patients(P＜0.05).The area under the curve(AUC)of TRPV1,TIMP4,TGF-β1 and their combined prediction of recurrence in BPPV patients were 0.795(95%CI:0.748-0.838),0.803(95%CI:0.756-0.845),0.810(95%CI:0.764-0.851)and 0.945(95%CI:0.914-0.967),respectively.The combined detection value of TRPV1,TIMP4 and TGF-β1 levels were better than that of single detection in predicting the recurrence in BPPV patients(all P＜0.05).Conclusion The serum levels of TRPV1,TIMP4 and TGF-β1 are independent factors affecting the recurrence of BPPV patients,and the combination of the three has a higher predictive value for the recurrence of BPPV patients.
