Advances in research on mechanisms of miRNA in viral and bacterial co-infections
10.11816/cn.ni.2025-250196
- VernacularTitle:miRNA在病毒和细菌共感染中的作用机制研究进展
- Author:
Chenjing YU
1
;
Jiaxuan BIAN
;
Huiqun JIA
;
Huanhuan LU
;
Mingjuan YANG
;
Ligui WANG
;
Hongbin SONG
Author Information
1. 郑州大学公共卫生学院,河南郑州 450001;中国人民解放军疾病预防控制中心传染病防控科,北京 100071
- Publication Type:Journal Article
- Keywords:
miRNA;
Virus;
Bacterium;
Co-infection;
Immune response
- From:
Chinese Journal of Nosocomiology
2025;35(20):3182-3187
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA(miRNA)serves as a novel regulatory factor in viral and bacterial co-infections,exhibiting dual regulatory roles during pathogen infections.On the one hand,it exerts protective effects by modulating viral replication cycles and host anti-infection immune responses.On the other hand,it can be exploited by pathogens to promote infection progression,including influencing viral replication,antiviral immune responses,and regulating bacterial adhesion and proliferation.Mixed viral and bacterial infections lead to high mortality rates.By binding to specific target gene mRNA,miRNA degrades or inhibits its translation,thereby regulating target gene expres-sion,which may ultimately serve as potential diagnostic and therapeutic targets.This paper reviews recent ad-vances in research on the role of miRNA in viral and bacterial infections,particularly its mechanisms in co-infec-tions,aiming to provide theoretical reference for further research on the infection mechanisms.
