Association of miR-26a and TLR4 expression in patients with condyloma acuminatum and their clinical characteristics with high-risk HPV infection
10.11816/cn.ni.2025-250583
- VernacularTitle:尖锐湿疣患者miR-26a和TLR4表达及临床特征与高危型HPV感染的关联
- Author:
Wei LEI
1
;
Lirui ZHAN
1
;
Meng LI
1
;
Jun ZHANG
1
;
Liuqing CHEN
1
Author Information
1. 武汉市第一医院皮肤科,湖北武汉 430000
- Publication Type:Journal Article
- Keywords:
Condyloma acuminatum;
MicroRNA-26a;
Toll-like receptor 4;
Clinical characteristic;
High-risk hu-man papillomavirus;
Predictive value
- From:
Chinese Journal of Nosocomiology
2025;35(20):3119-3123
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the association of microRNA-26a(miR-26a),Toll-like receptor 4(TLR4)expression in patients with condyloma acuminatum and their clinical characteristics with high-risk human papillo-mavirus(HPV)infection.METHODS A total of 103 patients with condyloma acuminatum treated at Wuhan No.1 Hospital from Jul.2023 to Jun.2024 were enrolled as the study group,and their wart tissues were collect-ed.Additionally,skin tissues from 50 healthy individuals undergoing physical examinations during the same peri-od were selected as the control group.The expression levels of miR-26a and TLR4 in both groups were measured and compared.HPV infection status in the study group was detected,clinicopathological characteristics of patients were collected and their relationship was analyzed.Based on high-risk HPV infection status,patients were divid-ed into a high-risk group(n=51)and a low-risk group(n=52).Receiver operating characteristic(ROC)curves were plotted to evaluate the predictive value of miR-26a and TLR4 in wart tissues for high-risk HPV infection.RESULTS The levels of miR-26a and TLR4 in wart tissues of the study group were(2.21±0.64)and(11.41±2.23),respectively,significantly higher than those in the control group(1.31±0.43 and 7.16±2.11,respectinely)(P＜0.05).No statistically significant differences in the expression level of miR-26a and TLR4 were observed in the wart tissues from patients with condyloma acuminatum,regardless of genders,ages,lesion loca-tions or wart numbers;however,significant differences were found among those with different disease durations,wart sizes and high-risk HPV infection status(P＜0.05).ROC curve analysis revealed that the areas under the curve(AUC)for miR-26a,TLR4 and their combined detection were 0.762,0.743 and 0.905,respectively,indi-cating good predictive value for high-risk HPV infection in patients with condyloma acuminatum(P＜0.05).CONCLUSIONS Both miR-26a and TLR4 protein are abnormally expressed in condyloma acuminatum tissues and demonstrate good predictive potential for high-risk HPV infection,suggesting their utility as biological markers and therapeutic targets for condyloma acuminatum.
