Advances in research on epidemiological characteristics,virulence evolution and drug resistance of hypervirulent Klebsiella pneumoniae
10.11816/cn.ni.2025-250704
- VernacularTitle:高毒力肺炎克雷伯菌的流行病学和毒力进化及其耐药性研究进展
- Author:
Meidi REN
1
;
Sisi CHEN
;
Jun LIU
Author Information
1. 江南大学无锡医学院,江苏无锡 214000
- Publication Type:Journal Article
- Keywords:
Hypervirulent Klebsiella pneumoniae;
Virulence factor;
Drug resistance;
Convergence;
Virulence plasmid;
Carbapenem resistance gene
- From:
Chinese Journal of Nosocomiology
2025;35(19):3020-3024
- CountryChina
- Language:Chinese
-
Abstract:
Hypervirulent Klebsiella pneumoniae(hvKP)is a highly pathogenic pathogen that is more virulent than classic Klebsiella pneumoniae(cKP)and often leads to severe disseminated infections.The horizontal transfer of virulence plasmids and carbapenem-resistant genes in hvKP through plasmids and mobile genetic elements(MG-Es)has led to the emergence of carbapenem-resistant(CR)-hvKP,posing a serious threat to public health.A deep understanding of the epidemiological characteristics,pathogenic mechanisms and convergence of virulence and drug resistance in hvKP is crucial for preventing and monitoring infections caused by this bacterium.
