Role of SHP2 in development of colitis-associated colon cancer and colorectal cancer and its potential as a therapeutic target

VernacularTitle:SHP2在结肠炎相关性结肠癌与结直肠癌发展中的作用及其作为治疗靶点的研究进展
Author: Hao ZHANG ¹ ; Qingfei DIAO ; Jianchun FAN ; Meng LI ; Juming JIA ; Chunbaixue YANG ; Xueliang WU
Author Information

1. 河北北方学院,河北张家口 075000
Publication Type:Journal Article
Keywords: tyrosine phosphatase; SHP2,PTPN11; colorectal cancer; colitis-associated colon cancer
From: Chinese Journal of Comparative Medicine 2025;35(1):163-171
CountryChina
Language:Chinese
Abstract: Colorectal cancer(CRC)is one of the most common malignant life-threatening tumors,with serious impacts on patient quality of life.Src homology 2 domain-containing protein tyrosine phosphatase(SHP2)has recently become a hot topic in the field of cancer research,and has demonstrated a close relationship with CRC.SHP2,encoded by the PTPN11 gene,is a non-receptor tyrosine kinase commonly present in various tissues and cells of the human body.Existing research shows that SHP2 plays a crucial role in regulating CRC and colitis-associated colon cancer(CAC),and the emergence of SHP2 allosteric inhibitors has identified SHP2 as a potential new therapeutic target for patients with CRC.Here we review the structure of SHP2 and its roles in CRC and CAC.