Progress in animal models of pollen-induced allergic rhinitis
10.3969/j.issn.1671-7856.2025.01.010
- VernacularTitle:花粉诱导的过敏性鼻炎动物模型研究进展
- Author:
Dan XU
1
;
Shanshan LI
1
;
Yili WANG
1
;
Feihong GAO
1
Author Information
1. 天津中医药大学,天津 301617
- Publication Type:Journal Article
- Keywords:
seasonal allergic rhinitis;
allergic rhinitis;
pollen allergens;
animal model
- From:
Chinese Journal of Comparative Medicine
2025;35(1):92-110
- CountryChina
- Language:Chinese
-
Abstract:
Pollen allergen-induced allergic rhinitis(AR),also known as seasonal allergic rhinitis(SAR),typically manifests during the period of pollen dissemination by anemophilous plants.The prevalence of SAR has more than doubled over the past three decades.The etiology of SAR is multifaceted,involving factors such as pollen allergens,environmental and climatic conditions,genetic predispositions,and the immunological status of the individual.Animal models provide a critical tool for elucidating the mechanisms underlying AR and advancing the development of effective preventive and therapeutic strategies.This review synthesizes the recent pertinent domestic and international literature on pollen-sensitized AR animal experiments.It systematically delineates the factors influencing the efficacy of these models,including the selection of animal strains,the production and associated challenges of sensitizing agents,specifically pollen antigens,the utilization and limitations of adjuvants,the procedural steps involved in model creation,and the method ologies for evaluating model effectiveness.The insights provided are intended to offer guidance and support for the development of appropriate animal models of pollen-induced AR,thereby facilitating both fundamental and applied research in this area.
