Comparative study on the effects of different oxygen-breathing methods coupled with drugs in the treatment of sudden hearing loss
10.3760/cma.j.issn.1009-6906.2014.02.013
- VernacularTitle:不同吸氧方法联合药物治疗突发性聋的对比研究
- Author:
Jinjing ZHAO
1
;
Yan LYU
;
Naikeng MAI
;
Chen YANG
;
Kai WANG
;
Shuyi PAN
Author Information
1. 海军总医院
- Publication Type:Journal Article
- Keywords:
Sudden hearing loss;
Hyperbaric oxygen;
Drug treatment;
Pure tone audiometry
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2014;21(2):120-123
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare and observe the clinical effects of different oxygen-breathing methods coupled with drugs in the treatment of sudden hearing loss (SHL),so as to explore new approaches for the treatment of the illness.Methods In accordance with the set criteria,101 cases of sudden hearing loss admitted into the center from Feb.2011 to Aug.2013 were selected for our study.All the patients received injections of dexamethasone sodium phosphate,ginkgo leave extract injection and other drug treatment.Then,the patients were randomly allocated to groups A,B and C in accordance with different methods of oxygenbreathing.Group A (37 cases) received drug treatment coupled with 0.20 MPa hyperbaric oxygen (HBO) therapy; Group B (also 37 cases) received the same drug treatment coupled with 0.16 MPa HBO therapy; and Group C (27 cases) received the same drug treatment coupled with 0.10 MPa (normal pressure) oxygen maskbreathing.During HBO therapy,the feeling of ear stuffiness in 3 patients from group A and 6 patients from group B was worsened and "C curve" of tympanic acoustic impedance was shown,and these 9 cases changed to receive low pressure oxygen breathing at 0.07 MPa,and were assigned as group D.The remaining 34 patients in group A and 31 patients in group B were then respectively assigned as group A1 and group B1.Pure tone audiometry and tympanic acoustic impedance detection were performed in all the patients both before treatment and at d 14 after treatment.Results Total effective rates for groups A1,B1,C and D were 82.4％,83.9％,59.3％ and 77.8％ respectively.Pure tone average (PTA) were respectively increased by (43.7 ± 17.4) dB,(46.3±21.2)dB,(28.1 ± 12.3)dB and (41.9 ± 19.8)dB.When compared with the control group,statistical difference could be seen in total effective rates for groups A1 and B1 (x2 =6.218,P ＜ 0.05).PTA values of groups A1 and B1 were higher than that of group C (P ＜ 0.05),and the feeling of ear stuffiness in patients of group D was obviously lighter following treatment.Conclusions HBO therapy combined with dexamethasone sodium phosphate and ginkgo leave extract injection was an effective method for the treatment of SHL.HBO therapy at 0.16 MPa could achieve quite satisfactory results,and was economical as well.For patients with an obvious feeling of ear stuffiness could receive oxygen breathing at a pressure of 0.07 MPa.
