Distribution and drug resistance variation of pathogens isolated from sterile body fluids in a three-A hospital of Jiangxi Province from 2016 to 2023
10.11816/cn.ni.2025-250006
- VernacularTitle:2016-2023年江西省某三甲医院无菌体液分离菌分布及耐药性变迁
- Author:
Chunmei ZHU
1
;
Dandan WEI
;
Yangyang HAO
;
Yang LIU
;
Tianxin XIANG
Author Information
1. 南昌大学第一附属医院感染控制中心,江西南昌 330052
- Publication Type:Journal Article
- Keywords:
Sterile body fluid;
Distribution of bacteria;
Drug resistance;
Carbapenems;
Jiangxi Province
- From:
Chinese Journal of Nosocomiology
2025;35(17):2669-2674
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the distribution and drug resistance of the pathogens isolated from sterile body fluids in a hospital so as to provide reference for clinical treatment of the infections.METHODS The sterile body fluids specimens that were cultured positive for pathogens were retrospectively collected from a three-A hos-pital of Jiangxi Province between 2016 and 2023.The distribution and drug resistance of the isolated pathogens were observed.RESULTS Totally 16,658 strains of pathogens were isolated from the sterile body fluid speci-mens in 2016-2023,among which gram-negative bacteria accounted for 51.74％.The species of bacteria that ranked the top 5 places were as follows:Escherichia coli,Klebsiella pneumoniae,Staphylococcus epidermidis,Staphylococcus hominis,and Staphylococcus aureus.The isolation rates of methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococcus were 28.32％and 74.94％,respectively;the strains maintained high sensitivity to linezolid and vancomycin,with the drug resistance rates no more than 2.50％.The drug resistance rates of Enterococcus faecium and Enterococcus faecalis to linezolid and vancomycin were always less than 4.20％.Among the species of Enterobacter,the drug resistance rates of the E.coli strains to meropenem declined from 17.65％to 5.94％;conversely,the drug resistance rate of the K.pneumoniae strains to carbapenems reached high up to 54.36％,showing an upward trend on the whole.Among the non-fermenting gram-negative bacteria,the drug resistance rate of the A.baumannii strains to carbapenems remained high(about 80.00％);while the drug resistance rates of the P.aeruginosa strains to meropenem dropped from 60.71％down to 24.32％.CONCLUSIONS The gram-negative bacteria are dominant among the pathogens isolated from the ster-ile body fluids in the hospital between 2016 and 2023.Although some major species of drug-resistant pathogens are effectively under control,the pathogens isolated from the sterile body fluid specimens maintain varying degree of drug resistance to various types of antibiotics.
