Effect of omalizumab injection combined with compound glycyrrhizin tablets on chronic urticaria with low response to antihistamines
10.3969/j.issn.1006-5725.2025.08.018
- VernacularTitle:奥马珠单抗注射液联合复方甘草酸苷片治疗抗组胺药低反应慢性荨麻疹的效果
- Author:
Haixia SHI
1
;
Yuan GUO
1
;
Yanhua LI
1
;
Juping CHEN
1
;
Haochen YUAN
1
;
Yun ZHANG
1
Author Information
1. 扬州大学附属医院皮肤科(江苏 扬州 225000)
- Publication Type:Journal Article
- Keywords:
chronic urticaria;
omalizumab;
compound glycyrrhetinic acid glycoside;
antihista-mines;
therapeutic response
- From:
The Journal of Practical Medicine
2025;41(8):1212-1216
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effectiveness and safety of combining Omalizumab with compound glycyrrhetinic acid glycoside in the management of chronic urticaria that exhibits poor response to antihistamine therapy.Methods 92 patients with chronic urticaria who were treated with H1 antihistamines and still had symp-toms from February 2022 to February 2024 in the hospital were selected as the study subjects.The study partici-pants were randomly assigned to either the observation group,consisting of 46 cases,or the control group,also comprising 46 cases,using a random number table method.The control group received subcutaneous injection of omalizumab for treatment.The observation group was treated with oral compound glycyrrhizin tablets on the basis of the control group.After 24 weeks of treatment,compare the efficacy,adverse reactions,Urticaria Activity Score over 7 days(UAS7),Dermatology Life Quality Index(DLQI),Immunoglobulin(Ig)E,and High Sensitivity C-reactive protein(hs CRP)between the two groups,and record the recurrence rate.Results After treatment,the UAS7,DLQI,IgE and hs-CRP of both groups of patients decreased compared to before treatment,and the observation group demonstrated lower results compared to the control group(P<0.05).After treatment,the overall effectiveness rate in the observation group exceeded that of the control group(P<0.05),and the recurrence rate was lower than that of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of drugs(P>0.05).Conclusion The combination therapy of omali-zumab and compound glycyrrhetinic acid glycoside in the treatment of chronic urticaria patients with low response to antihistamines helps reduce IgE expression,improve treatment effectiveness,lower recurrence rates,and does not increase adverse drug reactions.
