Analysis of leukemia disease burden in children and adolescents aged 0-19 years in China from 1990 to 2021
10.11904/j.issn.1002-3070.2025.02.001
- VernacularTitle:1990-2021年中国0～19岁儿童和青少年白血病疾病负担分析
- Author:
Xinyu WANG
1
;
Siyu CAI
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院大数据中心(北京 100045)
- Publication Type:Journal Article
- Keywords:
Leukemia;
Burden of diseases;
Children;
Adolescents
- From:
Practical Oncology Journal
2025;39(2):73-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective The objective of this study was to analyze the disease burden trend of leukemia in children and ado-lescents aged 0-19 years in China from 1990 to 2021,and to provide a scientific evidence for the disease prevention and control strat-egy of this population.Methods The disease burden of leukemia in children and adolescents in China(excluding Taiwan)was ana-lyzed using the Global Burden of Disease Database 2021(GBD 2021),including incidence,prevalence,mortality,and disability-ad-justed life year(DALY).DALY consisted of two parts:years of life lost(YLL)and years lived with disability(YLD).The average an-nual percentage change(AAPC)was used to comprehensively evaluate the changing trends of various indicators from the disease bur-den of childhood leukemia in China from 1990 to 2021.Results In 2021,the age-standardized incidence,prevalence,mortality and DALY rates of the 0-19 years old population in China were 7.33/100,000,51.46/100,000,1.72/100,000,and 142.14/100,000,respectively.Among them,the age-standardized incidence,prevalence,mortality and DALY rates of males were higher than those of females.The incidence,prevalence,mortality and DALY rates of the 0-years old group were higher than those of other age groups.The age-standardized incidence,prevalence,mortality and DALY rates of acute lymphoblastic leukemia(ALL)were higher than those of other leukemia subtypes.From 1990 to 2021,the leukemia age-standardized incidence in the population aged 0 to 19 years did show a significant increase or decrease(AAPC=-0.32%,95%CI:-0.66%-0.02%);the age-standardized prevalence showed a sig-nificant increase(AAPC=3.05%,95%CI:2.68%-3.42%).While age-standardized mortality and DALY rates showed a downward trend(AAPC=-4.27%,95%CI:-4.53%-4.01%;AAPC=-4.3%,95%CI:-4.56%-4.05%).Conclusion From 1990 to 2021,the disease burden of leukemia in children and adolescents aged 0 to 19 years in China is increasing,the burden of death is de-creasing,and the total DALY is decreasing.The burden of leukemia in this group varies greatly among different ages,genders,and leu-kemia subtypes.
