Hierarchical differences in brain functional networks in unilateral mesial temporal lobe epilepsy patients with different outcomes after surgery
10.13929/j.issn.1003-3289.2025.09.004
- VernacularTitle:术后不同预后单侧颞叶癫痫患者脑功能网络层级差异
- Author:
Kanlin LIN
1
;
Shangwen XU
;
Xiaoyang WANG
;
Ligang SONG
;
Sifan QIU
;
Lidan LIN
;
Yaling CHEN
;
Yusi ZHANG
;
Ailing XIONG
;
Huanyun XU
;
Qingqing ZHANG
Author Information
1. 福建中医药大学福总教学医院(第九○○医院)放射诊断科,福建 福州 350025;中国人民解放军联勤保障部队第九○○医院放射诊断科,福建 福州 350025
- Publication Type:Journal Article
- Keywords:
epilepsy,temporal lobe;
anterior temporal lobectomy;
magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(9):1473-1476
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe hierarchical differences in brain functional networks in unilateral mesial temporal lobe epilepsy(mTLE)patients with different outcomes after surgery.Methods A total of 69 unilateral mTLE patients who underwent resection of epileptogenic lesion on the affected side were retrospectively enrolled.Based on Engel classification 1 year after surgery,the patients were divided into seizure free(SF)group and non-seizure free(NSF)group.Functional connectivity gradient analysis was employed to extract principal gradient explaining the highest variance on preoperative resting-state functional MRI(rs-fMRI),then the whole-brain gradient characteristics and principal gradient values within specific functional networks were compared between groups.Results Principal gradient connected default mode network(DMN)with sensorimotor network(SMN)along a continuous axis.Compared to SF group,NSF group showed a contracted gradient range at both ends(DMN and SMN)of the functional network and weakened hierarchical differentiation,and principal gradient value of DMN was higher,while that of SMN was lower than those in SF group(both P＜0.05).Conclusion Hierarchical differences in brain functional networks in unilateral mTLE patients with different outcomes after surgery mainly present as enhanced DMN and weakened SMN in NSF ones,and the latter two might serve as important neuroimaging markers for evaluating postoperative seizure recurrence.
