Prefrontal cortex hemoglobin concentration changes during a verbal fluency test in late-onset depression: a multi-channel near-infrared spectroscopy study
10.3760/cma.j.issn.1006-7884.2016.05.003
- VernacularTitle:晚发抑郁症患者词语流畅性测验下前额叶氧合血红蛋白浓度变化的近红外线光谱成像研究
- Author:
Weigang PAN
1
;
Xin MA
;
Changhao JIANG
;
Peixian MAO
;
Yanping REN
;
Feng BAO
;
Jing LIU
Author Information
1. 100088,首都医科大学附属北京安定医院老年科
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Frontal lobe;
Oxyhemoglobins;
Spectroscopy,near-Infrared;
Verbal fluency test
- From:
Chinese Journal of Psychiatry
2016;49(5):280-285
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate executive function in late-onset depression (LOD),to assess activation characteristics of prefrontal cortex and to examine the relationship between cognitive deficits and activation in the prefrontal regions.Methods Twenty-nine patients with LOD and 30 normal controls were included in this study.The severity of depression was evaluated by the 17-item Hamilton Depression Scale (HAMD17).Hemoglobin concentration changes in bilateral prefrontal areas were measured during verbal fluency test (VFT) using 44-channel near infrared spectroscopy (NIRS).Results (1) In LOD group,the correct scores of VFT were significantly lower than that of the control group(9.6±2.4 vs.11.3±2.2,t=-2.89,P＜0.01).(2) In VFT,the part of right prefrontal,left inferior frontal gyrus regions in LOD patients were significantly lower than controls (t=-3.54 to-2.02,all P＜0.05).(3) The score of VFT was negatively correlated with retardation factor score (r=-0.52,P＜0.01).In LOD group,the spearman correlation analysis showed that the part of prefrontal regions in the VFT was correlated with HAMD17 total score (right,CH4:r=-0.44,P＜0.01),retardation factor score (right,CH7:r=-0.53,P＜0.01;CH12:r=-0.48,P＜0.01;CH17:r=-0.40,P＜0.05,CH18:r=-0.48,P＜0.01;CH22:r=-0.46,P＜0.01;left,CH10:r=-0.41,P＜0.05;CH11:r=-0.57,P＜0.01;CH15:r=-0.45,P＜0.05),anxiety/somatization factor score (left,CH11:r=-0.44,P＜0.05;CH15:r=-0.45,P＜0.01) and agitata factor score (right,CH11:r=-0.38,P＜0.05;left,CH19:r=-0.38,P＜0.05).Conclusion LOD patients may have executive dysfunction and prefrontal dysfunction,which be positively related to severity of depressive symptoms.
