Association analysis of zinc finger protein 804A gene with bipolar disorders and its subtypes in Han Chinese
10.3760/cma.j.issn.1006-7884.2015.05.005
- VernacularTitle:锌指蛋白804A基因与中国汉族双相障碍及其亚型的关联分析
- Author:
Chen ZHANG
1
;
Zuowei WANG
1
;
Zhiguo WU
1
;
Wu HONG
1
;
Jun CHEN
1
;
Daihui PENG
1
;
Yiru FANG
1
Author Information
1. 200030,上海交通大学医学院附属精神卫生中心心境障碍科
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
Zinc finger protein 804A;
Genes
- From:
Chinese Journal of Psychiatry
2015;48(5):279-283
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential association between zinc finger protein 804A (ZNF804A) rs1344706 polymorphism and bipolar disorder as well as its subtypes.Methods A total of 304 bipolar Ⅰ disorder,442 bipolar Ⅱ disorder and 762 healthy controls subjects were recruited from Division of Mood Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,from November 2006 to August 2014.Rs1344706 was genotyped by SNaPshot genotyping assay.Results In comparison between the patients with bipolar disorder and controls,there were significant differences in the genotypic (TT:210(28.2％) vs.175(23.0％),TG:378(50.7％) vs.399(52.4％),GG:158 (21.2％) vs.188(24.7％)) and allelic (T:798(53.5％) vs.749(49.1％),G:694(46.5％) vs.775(50.9％)) distributions (x2=6.18,P=0.04,x2=5.68,P=0.017,respectively).The frequency of T allele in patients with bipolar disorder was higher than that in controls (OR=1.19,95％CI 1.03-1.37).After stratified by diagnosed subtypes,there were significant differences in the genotypic and allelic distribution between patients with bipolar Ⅰ disorder and controls (x2=7.57,P=0.02,x2=7.22,P=0.007).The frequency of T allele in patients with bipolar Ⅰ disorder was higher than those in controls (OR=1.30,95％ CI 1.07-1.56).In comparison between patients with bipolar Ⅱ disorder and controls,there was no significant difference in the distributions of genotype and allele.Conclusion There is positive association between rs1344706 polymorphism and bipolar Ⅰ disorder in a Chinese Han population.ZNF804A gene may confer susceptibility to bipolar Ⅰ disorder in Han Chinese.
