Analysis of Clinical Characteristics and Risk Factors of Severe and Critical Influenza in Children
10.3870/j.issn.1672-0741.25.01.005
- VernacularTitle:儿童重型和危重型流行性感冒临床特征及预后危险因素分析
- Author:
Shufan LIU
1
;
Qi DAI
;
Peng XIONG
Author Information
1. 华中科技大学同济医学院附属同济医院儿童重症医学科,武汉 430030
- Publication Type:Journal Article
- Keywords:
influenza;
severe type;
critical type;
clinical feature;
risk factor
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(2):228-233
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics of severe and critical influenza children and analyze the risk factors affecting the prognosis of children.Methods Clinical data from children diagnosed with severe and critical influenza who were hospitalized in the pediatric intensive care unit of Tongji hospital,Tongji Medical College,Huazhong University of Science and Technology from January 2020 to December 2023 were retrospectively collected and analyzed.Results Among the 121 children,86 cases had severe influenza and 35 cases had critical influenza.There were 102 children in the good prognosis group and 19 children in the poor prognosis group.In all,93 cases(76.9％)were infected with influenza A,27 cases(22.3％)were in-fected with influenza B,and 1 case(0.8％)was infected with both influenza A and B.Sixty-seven cases(55.4％)were under 5 years old.The main clinical manifestations were fever,cough and convulsions.Seventy-five cases(62.0％)were complicated with pneumonia,65 cases(53.7％)were diagnosed with influenza-associated encephalopathy,and 22 cases(18.2％)developed multiple organ dysfunction syndrome.Fifty-five cases(45.5％)were infected with other pathogens,21 cases(17.4％)had bacterial infec-tion.The incidence of bacterial infection in children with critical influenza(31.4％)was higher than that in children with severe influenza(11.6％)(P＜0.05).Bacterial infection,neurological symptoms and elevated PCT were independent risk factors for poor prognosis(P＜0.05).Conclusion Children under 5 years old are more likely to develop severe and critical influen-za.Bacterial co-infection increases the risk of poor prognosis.Poor-prognostic severe or critical influenza is often accompanied by neurological manifestations and residual neurological sequelae.
