Amplitude of low-frequency fluctuations of the first-degree relatives of schizophrenia patients:a resting-state functional magnetic resonance imaging study
10.3760/cma.j.issn.1006-7884.2014.03.003
- VernacularTitle:精神分裂症患者一级亲属的静息态功能磁共振低频振幅研究
- Author:
Lin TIAN
1
;
Hao YAN
;
Qiang ZHAO
;
Yunbiao ZHANG
;
Weihua YUE
;
Dai ZHANG
Author Information
1. 无锡市精神卫生中心
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Magnetic resonance imaging;
First-degree relatives
- From:
Chinese Journal of Psychiatry
2014;47(3):137-141
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the differences of brain function between the first-degree relatives of schizophrenia patients and normal controls with resting-state functional magnetic imaging (fMRI).Methods Fifty-five unaffected biological fathers or mothers of schizophrenia patients and twenty-nine ageand gender-matched controls were enrolled and screened by experienced psychiatrists with a unstructured interview in this study.Then a resting-state fMRI scan was conducted for each participant.Amplitude of lowfrequency fluctuations (ALFF) approach was used to explore the differences of resting-state brain function between parents and controls.Results Compared with the controls,unaffected parents showed significantly decreased ALFF in the right middle temple cortex,middle cingulate cortex,superior frontal cortex/middle frontal cortex,triangular part of inferior frontal cortex and bilateral angular cortices.Parents also showed significantly increased ALFF in the bilateral lingual cortices (left:Montreal Neurological Institute(x,y,z):-12,-81,3,t =4.08,right:Montreal Neurological Institute (x,y,z):9,-57,3,t =3.88,P ＜ 0.01,corrected).Conclusions The results indicate there are dysfunctions of brain areas in the first-degree relatives of schizophrenia patients during resting state,which may reflect a genetic risk for schizophrenia.
