A case of multiple intracranial venous sinus thrombosis caused by primary thrombocythemia with CALR gene mutation
10.3969/j.issn.1002-0152.2025.03.007
- VernacularTitle:CALR基因突变引起的原发性血小板增多症致颅内多发静脉窦血栓形成1例
- Author:
Xiaochen GONG
1
;
Yi YANG
1
;
Zhaokun LI
1
;
Xinyu ZOU
1
;
Jiacai ZUO
1
;
Yufeng TANG
1
Author Information
1. 电子科技大学医学院附属绵阳医院,绵阳市中心医院神经内科(绵阳 621000)
- Publication Type:Journal Article
- Keywords:
Calreticulin gene mutation;
Primary myelofibrosis;
Cerebral venous sinus thrombosis;
Mechanical thrombectomy;
Catheter-directed thrombolysis
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(3):165-168
- CountryChina
- Language:Chinese
-
Abstract:
A case of multiple intracranial venous sinus thrombosis caused by a calreticulin(CALR)gene mutation in essential thrombocythemia is reported including the diagnosis,treatment process and outcome.The patient was a 39-year-old female presenting with headache,slurred speech and limb weakness.Physical examination revealed unclear speech,dysarthria and decreased muscle strength in the left limb.On the basis of anticoagulation therapy,mechanical thrombectomy,intrasinus contact thrombolysis,decompressive craniectomy and cytoreductive therapy targeting the cause were performed.After treatment,the venous sinuses were completely recanalized and the prognosis was good.There are no relevant literature reports on intracranial venous sinus thrombosis caused by CALR gene mutation in essential thrombocythemia.The diagnosis and treatment strategy of this case provide a reference for the identification and treatment of similar cases in clinical practice.
