18F-fluorodeoxyglucose positron emission tomography changes in brain glucose metabolism in patients with hypochondriasis
10.3760/cma.j.issn.1006-7884.2013.02.010
- VernacularTitle:疑病症患者脑葡萄糖代谢改变的正电子发射断层显像研究
- Author:
Da-liang SUN
1
;
Chun QIU
;
Yi-yun CAI
;
Zhi-yang WANG
;
Shen-xun SHI
;
Yi-hui GUAN
;
Feng-chun HUA
Author Information
1. 复旦大学附属华山医院精神医学科,上海,200040
- Publication Type:Journal Article
- Keywords:
Hypochondriasis;
Brain;
Positron emission tomography
- From:
Chinese Journal of Psychiatry
2013;46(2):104-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the brain glucose metabolism in hypochondriasis with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) compared with health subjects.Methods Eleven patients diagnosed as hypochondriasis according to CCMD-3 criteria and 23 age-and sex-matched healthy subjects were performed FDG PET/CT scan.All FDG-PET images were spatially normalized using statistical parametric mapping (SPM8; http://www.fil.ion.ucl.ac.uk/spm/) with an original template of SPM.Then the study analyzed the differences between the two groups to compare regarding respective FDG metabolism.Results Voxel-wise comparison of FDG-PET images was conducted using SPM8 to identify the brain regions showing glucose hypermetabolism in the right angular gyrus and inferior parietal lobule (Z =4.72),right insula (Z =4.19),right precentral gyrus (Z =4.15) and paracentral lobule (Z =3.52),right precuneate gyrus (Z =4.09),right middle (Z =3.39) and inferior frontal gyrus (Z =3.79),left posterior cingulate (Z =3.95),left precuneate gyrus (Z =3.98),left precentral gyrus (Z =3.72),bilateral thalamus,mesencephalon and lentiform nucleus (Z≥3.94).In addition,glucose hypometabolism was found in the fight superior temporal gyrus (Z =4.05),right gyrusrectus (Z =3.93),right superior frontal gyrus(Z =3.14) and left gyrusrectus(Z =3.59) in comparison with that of the normal subjects(P ＜ 0.001).Conclusions Hypochondriasis patients could have abnormal glucose metabolism in multiple regions of brain,which may involve the regulation of the pathophysiology in the central nervous system.
