Correlation analysis between amide proton transfer weighted imaging of the brain and the clinical psychological scale assessment in patients with Alzheimer's disease
10.3969/j.issn.1002-1671.2025.11.004
- VernacularTitle:阿尔茨海默病脑酰胺质子转移加权成像与临床心理量表评估的相关性分析
- Author:
Rui LI
1
;
Haohua WU
;
Da ZOU
;
Shan DENG
;
Lizhao HUANG
;
Rui WANG
;
Tao LI
Author Information
1. 柳州市工人医院医学影像科,广西 柳州 545007
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
amide proton transfer weighted imaging;
clinical psychological scale;
hippocampal head
- From:
Journal of Practical Radiology
2025;41(11):1777-1780
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between amide proton transfer weighted(APTw)imaging of the brain and the clinical psychological scale assessment in patients with Alzheimer's disease(AD).Methods A total of 30 AD patients(AD group)and 33 gender-and age-matched healthy volunteers(control group)were selected and all patients underwent brain MRI,magnetic resonance angiography(MR A)and APTw imaging examinations.According to the APTw images,the magnetization transfer ratio asym-metry(MTRasym)at 3.5 ppm values of each brain region were measured.The differences in MTRasym(3.5 ppm)values of each brain region between the AD group and the control group were compared,and then the diagnostic efficacy of MTRasym(3.5 ppm)values with significant differences were further analyzed.The correlations between the MTRasym(3.5 ppm)values of each brain region and scores of the mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)were analyzed.Results Compared with the control group,the MTRasym(3.5 ppm)values of the left hippocampal head in the AD group were significantly increased(P＜0.05).The area under the curve(AUC)of the receiver operating characteristic(ROC)curve of MTRasym(3.5 ppm)values of the left hippocampal head was 0.656(P＜0.05).MTRasym(3.5 ppm)values of the left hippocampal head,right temporal white matter,and bilateral occipital white matter were significantly negatively correlated with MoCA score(P＜0.05).Conclusion APTw imaging can effectively reflect the changes of protein concentration of the brain regions in AD patients,and is associated with cognitive func-tion,providing a new approach and method for early non-invasive diagnosis and disease monitoring of AD.
