Progress in understanding TREM macrophage-mediated signaling pathways in myocardial infarction
10.3969/j.issn.1671-7856.2025.10.011
- VernacularTitle:TREM巨噬细胞介导信号通路在心肌梗死中的研究进展
- Author:
Jing WANG
1
;
He WANG
1
;
Xia WANG
1
;
Shilong LI
1
;
Zhuo ZHAO
1
Author Information
1. 河南中医药大学第一附属医院,心脏中心/国家区域(中医)心血管诊疗中心,郑州 450046;河南省中西医防治重大疾病河南省协同创新中心,郑州 450046
- Publication Type:Journal Article
- Keywords:
myocardial infarct;
TREM;
inflammatory reaction;
signaling pathway
- From:
Chinese Journal of Comparative Medicine
2025;35(10):101-111
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial infarction is a cardiovascular disease with high rates of fatality.New targets are needed for the development of novel therapeutics that can protect heart function and prevent heart failure.Triggering receptor expressed myeloid cell(TREM)is an activating transmembrane receptor belonging to the immunoglobulin superfamily.TREM-1 and TREM-2 are the most important TREM family members,and are predominantly expressed on the surface of myeloid cells.TREM-1 and TREM-2 have similar transmembrane glycostructures,but they play different roles in regulating inflammatory responses.TREM play an important role in the inflammatory response,myocardial remodeling,and myocardial cell regeneration after myocardial infarction.This review summarizes the functions,expression patterns,and ligand combinations of TREM-1 and TREM-2,and discusses the roles of their signaling pathways in myocardial infarction.New targets for the treatment of myocardial infarction are proposed.
