Relationship between GH/IGF-1 axis and type 2 diabetic kidney disease in adults
- VernacularTitle:GH/IGF-1轴与成人2型糖尿病肾病相关性分析
- Author:
Zhengfang YANG
1
;
Chunhong ZHANG
;
Jing XU
;
Yang JIAO
;
Juanjuan WU
;
Shimei DING
;
Peng DONG
;
Jing ZHANG
Author Information
- Publication Type:Journal Article
- Keywords: growth hormone(GH); insulin like growth factor 1(IGF-1); type 2 diabetes mellitus kidney disease; insulin resistance
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2025;46(6):960-965
- CountryChina
- Language:Chinese
- Abstract: Objective This study examined changes in serum growth hormone(GH)and insulin-like growth factor 1(IGF-1)levels,as well as insulin resistance,in patients with type 2 diabetes mellitus(T2DM)across different stages of diabetic kidney disease(DKD).It explored the relationship between these factors and the occurrence and progression of DKD,with the aim of identifying new targets for the prevention and treatment of DKD.Methods In this cross-sectional study,T2DM patients aged 18-80 years were selected from the Department of Endocrinology,The Second Affiliated Hospital of Xi'an Jiaotong University,from November 30,2019 to March 30,2021.Their serum GH and IGF-1 levels were tested.Results The serum GH level increased gradually in the groups,and the difference was statistically significant(P＜0.05).The level of serum IGF-1 decreased first and then increased among the groups,but with no significant difference(P＞0.05).HOMA-IR showed no significant correlation among the groups(P＞0.05),but HOMA-β gradually decreased among the groups,with statistically significant difference(P＜0.05).Multivariate Logistic regression analysis showed that the increase of serum GH level was closely related to the progression of T2DM to early DKD,and that the increase of serum IGF-1 level might be related to the deterioration of renal function in patients with T2DM at DKD stage.HOMA-IR and HOMA-β were not found to have correlation with the occurrence or development of DKD in T2DM patients.Conclusion In patients with T2DM,elevated serum GH level is closely associated with the occurrence and progression of early DKD.The increase of serum GH level may promote the occurrence of early DKD in T2DM,and the increase of serum IGF-1 level may be related to the deterioration of renal function in clinical DKD stage.In this study,we did not find correlation of HOMA-IR and HOMA-β with the occurrence or development of DKD in T2DM patients.
