Effects of simulated aircraft cabin pressure change on gallstone formation of rabbits
10.3760/cma.j.issn.1007-6239.2014.02.004
- VernacularTitle:模拟民航客机飞行中的气压变化对家兔胆囊结石形成的影响
- Author:
Mai ZHOU
1
;
Tianmu LI
1
;
Wuyi DENG
1
;
Gangjun JIAO
1
;
Daqing WANG
1
Author Information
1. 民航总医院,北京,100123
- Publication Type:Journal Article
- Keywords:
Air pressure;
Radioisotopes;
Cholecystolithiasis;
Bile
- From:
Chinese Journal of Aerospace Medicine
2014;25(2):96-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of cabin pressure change on gallstone formation by using hypobaric chamber to simulate hypobaric circumstance of civil aircraft in flight.Methods Forty-eight rabbits were randomly divided into control group (n＝ 12) that was with fodder,test group A (n ＝ 12) that was with 0.8％ cholesterol fodder,test group B (n ＝ 12) that was with standard fodder and hypobaric exposures 2 h a day for 28 days,and test group C (n＝12) that was with 0.8% cholesterol fodder and hypobaric exposures once a day for 28 days.The rate of gallstone formation was calculated for each group respectively.Quantitative analyses of 99 mTc-EHIDA hepatobiiiary dynamic image,the bile viscosity and bile ingredient were made for each group.Results ①The rate of gallstone formation was 0.0% in control group,50.0% in test group A (6/12),8.3％ in test group B (1/12) and 66.7％ in test group C (8/12).(②)Compared with control group,test group A,B and C showed significant delay in duodenal appearance time (DAT) (t＝4.779-17.093,P＜0.01).DAT of test group C was longer than that of test group A and test group B respectively (t＝2.693,5.654,P＜0.05 or P＜0.01).③Compared with control group,test group A and C showed higher high shear rate and low shear rate (t＝2.063 2.343,P＜0.05),and test group C had higher medium shear rate (t＝2.111,P＜0.05).(④) Compared with control group and test group B,test group A and test group C had higher level of bile acid (t 2.001 2.017,P＜0.05) and higher level of cholesterol (t＝ 2.445 2.762,P＜0.05).The level of phospholipid of test group C was lower than that of control group and test group B (t＝2.447,2.320,P＜0.05).Conclusions High cholesterol intake and barometric pressure change in flight would facilitate the gallstone formation in rabbits to some extent.
