Association between childhood trauma and prefrontal functional networks in early adulthood
10.3969/j.issn.1000-6729.2025.10.08
- VernacularTitle:童年创伤与成年早期前额叶功能网络的关联研究
- Author:
Shanling JI
1
;
Qiuling WANG
;
Yue WANG
;
Rui WANG
;
Maoxuan SU
;
Bingqian LIU
;
Xinyu LIN
;
Siqi JIA
;
Yuxin DU
;
Yuzhou CHEN
;
Hao YU
Author Information
1. 济宁医学院精神卫生学院,山东济宁 272067
- Publication Type:Journal Article
- Keywords:
childhood trauma;
Iowa game task;
functional near-infrared spectroscopy;
brain functional net-work;
rumination
- From:
Chinese Mental Health Journal
2025;39(10):880-887
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between childhood trauma and prefrontal cortex functional networks in early adulthood using functional near-infrared spectroscopy(fNIRS).Methods:Twenty-eight individu-als with childhood trauma comprised the trauma group,while 32 without trauma formed the control group.The Childhood Trauma Questionnaire(CTQ)assessed abuse and neglect,the Ruminative Responses Scale(RRS)meas-ured repetitive thinking about negative events,and the Iowa Gambling Task(IGT)evaluated decision-making tend-encies.fNIRS data collected during the IGT were used to calculate degree centrality(DC),betweenness centrality(BC),and local efficiency(LE)in prefrontal networks.Mediation analysis explored relationships among childhood trauma,brain function(DC,BC,LE),and ruminative thinking.Results:Compared to controls,the trauma group had decreased DC in bilateral dorsolateral prefrontal cortices,increased DC,BC,and LE in the right inferior frontal gy-rus,and elevated LE in the bilateral frontal poles.BC and LE in the right inferior frontal gyrus partially mediated the relationship between CTQ sexual abuse and RRS scores(48.57％and 41.43％,respectively).Conclusion:Child-hood trauma is significantly associated with changes in prefrontal network properties in early adulthood.Sexual a-buse,in particular,may influence emotional regulation and cognitive functions by altering the network attributes of the right inferior frontal gyrus.
