Diagnostic value of PIV,APRI,and FIB-4 in intrahepatic cholestasis of pregnancy
10.3969/j.issn.1673-9701.2025.26.009
- VernacularTitle:PIV、APRI和FIB-4对妊娠期肝内胆汁淤积症的诊断价值
- Author:
Congshan SONG
1
;
Yuwen GUO
1
Author Information
1. 安徽医科大学妇幼医学中心产科,安徽 合肥 230000;安徽医科大学第五临床学院,安徽 合肥 230000;安徽省妇女儿童医学中心产科,安徽 合肥 230000;合肥市妇幼保健院产科,安徽 合肥 230000
- Publication Type:Journal Article
- Keywords:
Intrahepatic cholestasis of pregnancy;
Pan-immune-inflammation value;
Fibrosis-4
- From:
China Modern Doctor
2025;63(26):33-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of pan-immune-inflammation value(PIV),aspartate aminotransferase to platelet ratio index(APRI)and fibrosis-4 index(FIB-4)in intrahepatic cholestasis of pregnancy(ICP).Methods A total of 312 pregnant women who underwent prenatal care and childbirth at Anhui Women and Children's Medical Center from September 2022 to December 2024 were selected as subjects.Among them,156 patients diagnosed with ICP were included in ICP group,while 156 healthy pregnant women formed control group.The study compared differences in PIV,APRI,and FIB-4 levels between two groups.Receiver operating characteristic(ROC)curves were used to evaluate the predictive capabilities of PIV,APRI,and FIB-4 indicators for ICP occurrence,both individually and in combination.Results Inflammatory response is involved in the occurrence of ICP,and PIV,APRI,and FIB-4 have good diagnostic value for ICP.When PIV and APRI are combined,they have higher diagnostic value in ICP group showed significantly higher PIV,APRI,and FIB-4 levels compared to control group(P＜0.05).The area under the curve(AUC)for diagnosing ICP using PIV,APRI,and FIB-4 were 0.636,0.751,and 0.627,respectively.When PIV combined with APRI,the diagnostic AUC reached 0.829 with sensitivity of 73.1％and specificity of 83.3％.Conclusion Inflammatory response is involved in the occurrence of ICP,and PIV,APRI and FIB-4 have good diagnostic value for ICP.Combination of PIV and APRI shows excellent diagnostic value.
