Effect of carbon dioxide fractional laser combined with glucocorticoid on follicular helper T cells and B cell subsets in patients with advanced vitiligo
10.3969/j.issn.1000-484X.2025.05.025
- VernacularTitle:二氧化碳点阵激光联合糖皮质激素治疗对进展期白癜风患者滤泡辅助性T细胞及B细胞亚群的影响
- Author:
Lina ZHANG
1
;
Chao LYU
1
;
Zhixia FAN
1
;
Xin WANG
1
;
Juan SHEN
1
;
Zhonglin ZHAO
1
;
Jun′e FENG
1
;
Guoying MIAO
1
Author Information
1. 河北工程大学附属医院皮肤科,邯郸 056002
- Publication Type:Journal Article
- Keywords:
Vitiligo;
Advanced;
CO2 fractional laser;
Glucocorticoid;
T cells;
B cells
- From:
Chinese Journal of Immunology
2025;41(5):1175-1181
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of CO2 fractional laser combined with glucocorticoid(GC)on T follicular helper cell(Tfh)and B cell subsets in patients with advanced vitiligo(VL).Methods:Patients with advanced VL(128 cases)who were treated in Affiliated Hospital of Hebei University of Engineering from August 2019 to March 2022 were selected as research objects,and divided into group A(64 cases,CO2 fractional laser combined with GC)and group B(64 cases,CO2 fractional laser)according to different treatment methods,clinical efficacy and safety of the two groups were compared.Another healthy subjects(64 cases)were selected as control group.Collected clinical data of the three groups of subjects for comparative analysis.Randomized walking model was used to evaluate the effect of CO2 fractional laser combined with GC on immune function and inflammatory response in patients with advanced VL.Results:Compared with group B,group A had a higher clinical total effective rate(P<0.05)and a lower probability of adverse reactions(P<0.05).After treatment,compared with control group,proportion of Tfh2 and Tfh17 in group A had no significant difference(P>0.05),while proportion of Tfh2 and Tfh17 in group B still had significant difference(P<0.05);compared with group B,proportion of Tfh2 in group A after treatment was higher(P<0.05),while proportion of Tfh17 type was lower(P<0.05).After treat-ment,compared with control group,proportion of memory transformed B cell in group B was still significantly different(P<0.05).After treatment,compared with control group,levels of IgA,IgE and IgM in group B were still significantly different(P<0.05);compared with group B,level of IgM in group A was higher after treatment(P<0.05).After treatment,compared with control group,levels of IL-21 and IL-1β in group B were still significantly different(P<0.05);compared with group B,level of IL-10 in group A after treatment was higher(P<0.05),while levels of IL-21 and IL-1β were lower(P<0.05).Evaluation results of random walking model showed that the improvement of immune function and inflammatory reaction in group A was better than that in group B.Conclusion:CO2 fractional laser combined with GC can improve the immune function and inflammatory reaction of patients with advanced VL better after treatment,and the probability of adverse reactions is lower.
