Mendelian randomization analysis of causal association between schizophrenia and lung cancer
10.3969/j.issn.1000-6729.2025.10.06
- VernacularTitle:孟德尔随机化方法评估精神分裂症与肺癌的因果关联
- Author:
Kangming HUO
1
;
Minghu CUI
;
Zhongwen ZHANG
Author Information
1. 滨州医学院公共卫生学院,山东烟台 264003
- Publication Type:Journal Article
- Keywords:
schizophrenia;
lung cancer;
causal association;
Mendelian randomization
- From:
Chinese Mental Health Journal
2025;39(10):868-874
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the association between schizophrenia and risk of lung cancer using Mende-lian randomization approach.Methods:Select instrumental variables from the genome-wide association study of the Psychiatric Genomics Consortium and the UK Biobank.Two-sample Mendelian randomization of the selected in-strumental variables was performed using the inverse variance weighted method as the primary method of analysis,with the weighted median method and the MR Egger method as complementary methods of analysis.Cochran Q test was applied to analyze the heterogeneity,and MR-Egger intercept analysis and leave-one-out method were applied for pleiotropy test to assess the reliability of the analysis results.Results:For the data on schizophrenia and lung cancer,the inverse variance weighted method assessed that the risk(OR)of lung cancer in patients with schizophre-nia was 1.001 times(95％CI:1.000-1.002,P＜0.01)higher than that of the general population.Both the weighted median method and the MR Egger method of assessments also indicated an increased risk of lung cancer in individuals with schizophrenia.Conclusion:Our findings suggest a potential causal association between schizo-phrenia and lung cancer.
