Chemical constituents from Periploca forrestii and their antitumor activity in vitro
10.3969/j.issn.1001-1528.2025.09.018
- VernacularTitle:黑骨藤化学成分及其体外抗肿瘤活性研究
- Author:
Zhen-hua YANG
1
;
Rui-xue YU
;
Piao-piao NING
Author Information
1. 平顶山学院,河南平顶山 467000;平顶山新华区和平路社区卫生服务站,河南平顶山 467000
- Publication Type:Journal Article
- Keywords:
Periploca forrestii Schltr;
chemical composition;
isolation and identification;
antitumor activity
- From:
Chinese Traditional Patent Medicine
2025;47(9):2942-2949
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from Periploca forrestii Schltr and their antitumor activity in vitro.METHODS Silica gel and Sephadex LH-20 were used for isolation and purification,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The in vitro antitumor activity was evaluated by MTT mothod.RESULTS Twenty-four compounds were isolated and identified as lysidicichin(1),fraxidin(2),methoxylatifolone(3),corilagin(4),ligballinol(5),6-dehydroprogesterone(6),anomallenodiol(7),mustakone(8),eupatoricacid(9),honokiol(10),methyl 4-hydroxybenzoate(11),5,6,7,8-tetramethoxycoumarin(12),6,7-dimethoxycoumarin(13),5,6,7,4'-tetramethoxyflavone(14),2,3,2",3"-tetrahydrospirotaxone(15),sequoiavone(16),isocubebin(17),isoquercitrin(18),mellein(19),pistaciamide(20),suberoyltrigone(21)、daucosterol(22)、berchemol(23)、confluentin(24).The IC50 value of compound 18 for lung cancer cell NCI-H596 was(27.41±3.36)μmol/L.CONCLUSION Compounds 1-24 are isolated from P.forrestii for the first time.Compound 18 has good antitumor activity in vitro.
