Clinical effects of Tongfu Jiangzhuo Formula on ICU delirium patients with Internal Accumulation of Turbid Toxins
10.3969/j.issn.1001-1528.2025.09.014
- VernacularTitle:通腑降浊方对浊毒内蕴证ICU谵妄患者的临床疗效
- Author:
Yan-na GENG
1
;
Xu DONG
;
Yan-tao LI
;
Yan DONG
Author Information
1. 河北省中医院重症医学科,河北石家庄 050000
- Publication Type:Journal Article
- Keywords:
Tongfu Jiangzhuo Formula;
conventional treatment;
ICU delirium;
Internal Accumulation of Turbid Toxins;
Turbid Toxins theory
- From:
Chinese Traditional Patent Medicine
2025;47(9):2918-2922
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of Tongfu Jiangzhuo Formula on ICU delirium patients with Internal Accumulation of Turbid Toxins.METHODS Based on Turbid Toxins theory,two hundred and ten patients were randomly assigned into control group(105 cases)for intervention of conventional treatment,and observation group(105 cases)for intervention of both Tongfu Jiangzhuo Formula and conventional treatment.The changes in clinical effects,delirium scores(CAM-ICU,ICDSC),TCM syndrome score,inflammatory factors(IL-1β,IL-6,IL-8),Raf-1,MEK-2,ERK-1 mRNA and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased delirium scores,TCM syndrome score,inflammatory factors and Raf-1,MEK-2,ERK-1 mRNA(P＜0.05),especially for the observation group(P＜0.05).No significant difference in incidence of adverse reactions was found between the two groups(P＞0.05).CONCLUSION For the patients with ICU delirium due to Internal Accumulation of Turbid Toxins,Tongfu Jiangzhuo Formula can safely and effectively improve symptoms,and reduce inflammation levels and Raf-1,MEK-2,ERK-1 mRNA expressions.
