Mendelian randomization study of endometriosis and trace elements
10.3969/j.issn.1673-9701.2025.27.003
- VernacularTitle:子宫内膜异位症与微量元素的孟德尔随机化分析
- Author:
Xinying ZHOU
1
;
Yingchun DUAN
;
Hu ZHANG
;
Zhanpeng ZHU
;
Haiyan DAI
Author Information
1. 宁波市医疗中心李惠利医院妇科,浙江宁波 315000
- Publication Type:Journal Article
- Keywords:
Trace elements;
Mendelian randomization;
Endometriosis;
Causality
- From:
China Modern Doctor
2025;63(27):13-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective The causal relationship between endometriosis(EMs)and 15 trace elements including copper,calcium,carotene,folic acid,iron,magnesium,potassium,selenium,vitamin A,vitamin B12,vitamin B6,vitamin C,vitamin D,vitamin E and zinc was analyzed by double sample Mendelian randomization(MR).Methods Multiple trace elements were used as exposure factors,and the incidence risk of EMs was used as the outcome factor for two-sample MR analysis.The data were sourced from the publicly available integrative epidemiology unit open Genome-Wide Association Studies database and Finnish Genome Research Project database.Five Mendelian randomization analysis methods were employed to investigate the causal relationship between EMs and trace elements.Additionally,sensitivity analysis was carried out to evaluate the influence of heterogeneity and horizontal pleiotropy on the results of the MR analysis.Results The impact of trace elements on various types of EMs varies.The results of the inverse variance weighted(IVW)method indicated that trace element calcium(OR=1.465,95％CI:1.094-1.962)and vitamin B6(OR=1.580,95％CI:1.146-2.178)might be risk factors for ovarian EMs.Vitamin B6(OR=0.203,95％CI:0.044-0.939)may be a protective factor for tubal EMs.The above research results were not affected by heterogeneity and horizontal pleiotropy(P＞0.05).This study did not find a causal relationship between other trace elements and EMs.Conclusion The trace elements calcium and vitamin B6 predicted by genetics may play a regulatory role in the development of EMs.
