Research status and progress in animal models of senile osteoporosis
10.3969/j.issn.1005-4847.2025.03.012
- VernacularTitle:老年性骨质疏松症动物模型研究现状与进展
- Author:
Tonghai ZHANG
1
;
Lining WANG
;
Yongkang HU
;
Tianci MA
;
Anyang HAN
;
Yong MA
;
Yang GUO
Author Information
1. 南京中医药大学第一临床医学院,南京 210029
- Publication Type:Journal Article
- Keywords:
senile osteoporosis;
animal models;
research progress
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(3):440-448
- CountryChina
- Language:Chinese
-
Abstract:
Senile osteoporosis is a growing public health challenge with significant impacts on the daily life of the elderly population as a result of its hidden nature,high prevalence,and high risk of disability.Suitable animal models that simulate senile osteoporosis are crucial for understanding its pathological mechanism and to facilitate the development of anti-osteoporosis drugs and identify new therapeutic targets.This review considers the most commonly used method for creating animal models of senile osteoporosis,analyzes their advantages and limitations,and discusses research progress in animal models in terms of evaluation indicators,to provide references for research using animal models of senile osteoporosis.
