Advances in research on an animal model of empty bottle stimulation stress anxiety
10.3969/j.issn.1005-4847.2025.03.010
- VernacularTitle:基于文献数据库的空瓶刺激应激诱导焦虑样行为的动物模型研究
- Author:
Yongzhi ZHAO
1
;
Yiwen ZHANG
;
Yanqin LUO
;
Fang CHEN
;
Mengchen DONG
;
Ruile PAN
;
Qi CHANG
;
Ning JIANG
;
Xinmin LIU
Author Information
1. 石河子大学药学院/新疆植物药资源利用教育部重点实验室,新疆石河子 832003;中国医学科学院北京协和医学院药用植物研究所,北京 100193
- Publication Type:Journal Article
- Keywords:
empty bottle stimulation model;
uncertainty empty bottled water stimulation;
emotional stress;
anxiety disorder;
animal model
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(3):420-429
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide a comprehensive review of the modeling method of the empty bottle stimulation(EBS)anxiety model,including commonly used experimental animal strains and genders,animal grouping,modeling procedures,modeling duration,primary behavioral evaluation method,and the underlying pathological mechanisms.This aims to offer a reference for the application of the EBS anxiety model in anxiety disorder research.Methods Searches were conducted in databases such as CNKI and PubMed to collect all literature related to the EBS anxiety model,which were then systematically summarized and organized.Results(1)Male adult SD or Wistar rats are predominantly used as experimental animals;(2)The optimal modeling period is 2 weeks;(3)Behavioral evaluations primarily utilize the open field test,elevated plus maze test,and light-dark box test;(4)Pathological mechanisms involve abnormal neurotransmitter metabolism in brain regions such as the hippocampus,prefrontal cortex,and amygdala.Conclusions The EBS anxiety model exhibits an anxiety-like behavioral phenotype and associated neurobiological mechanisms,validating its utility as an animal model for the study of anxiety disorders.However,further exploration and refinement are required for its standardized construction protocol and the understanding of its mechanistic underpinnings.
