Survival Analysis of Patients with Ovarian Carcinosarcoma Based on the SEER Database
10.3969/j.issn.1003-6946.2025.10.015
- VernacularTitle:基于SEER数据库的卵巢癌肉瘤患者生存分析
- Author:
Jinhong DING
1
;
Dongdong LI
1
;
Fanghao MA
1
;
Xiaoyue GAO
1
;
Xiaofeng XU
1
;
Huaijun ZHOU
1
Author Information
1. 南京鼓楼医院妇产科,江苏南京 210004
- Publication Type:Journal Article
- Keywords:
Ovarian carcinosarcoma;
Cytoreductive surgery;
Lymphadenectomy;
Chemotherapy
- From:
Journal of Practical Obstetrics and Gynecology
2025;41(10):852-858
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the survival outcomes and prognostic factors of patients with ovarian carcino-sarcoma(OCS)based on SEER database.Methods:The data of 1285 OCS patients from 2000 to 2018 in SEER database were retrospectively analyzed.Univariate and multivariate Cox proportional hazards models were used to evaluate the prognostic factors associated with overall survival(OS)and cancer specific survival(CSS).Kap-lan-Meier survival curve was drawn to evaluate the survival analysis of patients' prognosis after clinical treatment.Results:①The study cohort included a total of 1285 OCS patients,The mean age of these patients was 66.21±11.71 years.Most patients had already experienced regional(22.80％)or distant(72.22％)metastasis at the time of diagnosis.②Multivariate Cox regression revealed,SEER stage of regional or distant metastasis,no surger-y,no chemotherapy,and no lymphadenectomy were independent risk factors for both patient OS and CSS(HR＞1,P＜0.05).Age ≥67 years was an independent risk factor for OS(HR＞1,P＜0.05).Age ≥ 83 years was an in-dependent risk factors for CSS(HR＞1,P＜0.05).③Kaplan-Meier survival analysis showed that among surgical patients with adjacent tissue invasion or distant metastasis had significantly better overall survival rate after lymph node dissection than those without(P＜0.001);We didn't see the significantly different effects of lymphadenecto-my on patients with localized disease(P=0.266).Among all patients who underwent surgery,the overall survival rate of all patients who received adjuvant chemotherapy after surgery was significantly better than that of those who did not(P＜0.001).Conclusions:Prognosis of OCS patients is associated with age,SEER comprehensive stage,surgery status,chemotherapy status,lymphadenectomy status.Patients with OCS who underwent cytore-ductive surgery and adjuvant chemotherapy had a better prognosis.However,it is questionable whether lymph-adenectomy is necessary in OCS patients with very early stage.
