Effect of Melatonin on IVF-ET Pregnancy Outcome in Elderly Infertile Patients with Diminished Ovarian Reserve
10.3969/j.issn.1003-6946.2025.10.014
- VernacularTitle:褪黑素对高龄卵巢储备功能减退不孕患者体外受精-胚胎移植妊娠结局的影响
- Author:
Shengyan JIAN
1
;
Ronghua MA
;
Xiaona LI
;
Jinchun LV
;
Qingli HUANG
;
Zhengfang XIONG
Author Information
1. 青海省人民医院生殖医学中心,青海西宁 810001
- Publication Type:Journal Article
- Keywords:
Melatonin;
Advanced age;
Impaired ovarian reserve;
Infertility;
In vitro fertilization and embryo transfer
- From:
Journal of Practical Obstetrics and Gynecology
2025;41(10):847-851
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the impact of oral melatonin on clinical pregnancy outcomes in elderly infer-tile patients with diminished ovarian reserve(DOR)after in vitro fertilization and embryo transfer(IVF-ET).Methods:Sixty-two elderly infertile patients with DOR who underwent IVF at the Reproductive Medicine Center of Qinghai Province People's Hospital from January 1,2022 to June 30,2023 were selected.They were divided into intervention group(24 cases)and control group(38 cases)according to whether they received oral melatonin pretreatment before ovulation induction.Follicular fluid without diluent or blood contamination was collected from the first large follicle on the day of oocyte retrieval,and melatonin levels and 8-hydroxy-2'-deoxyglycoside(8-OHdG)levels in the follicular gluid were measured.Ovulation promotion indicators and pregnancy outcomes were compared and analyzed between the two groups.Results:The concentration of melatonin in follicular fluid in the intervention group was significantly higher than that in the control group(31.75 ng/L vs.10.40 ng/L,P＜0.001),the concentration of 8-OHdG was lower than that of the control group(133.61 ng/L vs.145.30 ng/L,P=0.004);the implantation rate in the intervention group was significantly higher than that in the control group(56.10％vs.26.87％,P=0.002),and the biochemical pregnancy rate in the intervention group was significantly higher than that in the control group(12.50％vs.0,P=0.050).There were no significant differences in normal fertilization rate,high-quality embryo rate,clinical pregnancy rate and cumulative live birth rate between the two groups(P＞0.05).Conclusions:Oral melatonin can increase its level in follicular fluid,which is beneficial in improving endom-etrial receptivity,and has a certain positive effect on improving IVF-ET outcomes.
