Study on the Correlation between TCM Syndrome Types of Diabetic Nephropathy Complicated with Atherosclerosis and WLR,PLR,MLR
10.16466/j.issn1005-5509.2025.09.011
- VernacularTitle:糖尿病肾病合并动脉粥样硬化中医证型与WLR、PLR、MLR的相关性研究
- Author:
Xiao'ou ZHU
1
;
Bijia ZHAO
;
Lifang CHEN
Author Information
1. 浙江中医药大学 杭州 310053;临海市中医院
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
atherosclerosis;
TCM syndrome types;
microscopic syndrome differentiation;
prognosis;
WLR;
PLR;
MLR
- From:
Journal of Zhejiang Chinese Medical University
2025;49(9):1157-1162
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the correlation between traditional Chinese Medicine(TCM)syndrome types in patients with diabetic nephropathy(DN)and leukocyte lymphocyte ratio(WLR),platelet/lymphocyte ratio(PLR),monocyte lymphocyte ratio(MLR).[Methods]A total of 227 patients with DN and AS were included in this study to analyze the changes of WLR,PLR,MLR,carotid intima-medial thickness(IMT)and the levels of WLR,PLR and MLR under different TCM syndrome types.Logistic analysis and receiver operating characteristic(ROC)curves were used to evaluate the application value of WLR,PLR and MLR in predicting the severity and prognosis of DN complicated with AS.[Results]Among the TCM syndrome types in patients with DN and AS,Qi and Yin deficiency syndrome accounted for the highest proportion,followed by spleen and kidney Yang deficiency syndrome,Yin and Yang deficiency syndrome,and turbidity and stasis obstruction syndrome.The levels of WLR,PLR,and MLR in patients with DN and AS from high to low were turbidity and stasis obstruction syndrome,Yin and Yang deficiency syndrome,spleen and kidney Yang deficiency syndrome,and Qi and Yin deficiency syndrome.WLR,PLR,MLR were positively correlated with IMT(P<0.05).Logistic analysis showed that the levels of WLR,PLR and MLR were correlated with the severity of DN and AS.ROC curve analysis indicated WLR,PLR,MLR had high value in evaluating the prognosis of DN combined with AS(P<0.05).[Conclusion]WLR,PLR and MLR are expected to be potential biological indicators for microscopic syndrome differentiation and prognosis evaluation of DN combined with AS in TCM.
