Advances in research on mitochondrial fission and fusion dynamics in allergic diseases
- VernacularTitle:线粒体分裂/融合动态变化在变应性疾病中的研究进展
- Author:
Kai-yuan HE
1
;
Long-yun ZHOU
;
Xu-qing CHEN
;
Yong-jun WU
Author Information
- Publication Type:Journal Article
- Keywords: mitochondrial dynamics; mitochondria; hypersensi-tivity; allergic diseases; mast cells; type 2 innate lymphocytes
- From: Chinese Pharmacological Bulletin 2025;41(5):820-824
- CountryChina
- Language:Chinese
- Abstract: Mitochondrial dynamics refer to two modes of move-ment:mitochondrial fission and mitochondrial fusion.Stimula-tion from internal and external sources promotes the occurrence of mitochondrial dynamic changes,supporting cellular functional changes to adapt to physiological and pathological changes.This article systematically reviews relevant literature,providing an o-verview of the dynamic changes in mitochondrial fission/fusion from both physiological and pathological perspectives.It summa-rizes the essence of these changes by highlighting functional al-terations,including ion homeostasis,redox balance,energy me-tabolism,and programmed death signaling,and reveals the un-derlying mechanisms of action.Additionally,by focusing on key cellular components in allergic diseases,it discusses the impact of functional alterations in mitochondrial dynamic division/fusion on allergic diseases.Progressively examining the concept,func-tional alterations,and impact on allergic diseases,this study es-tablishes a connection between mitochondrial fission/fusion dy-namics and key cellular components of allergic diseases.It con-structs a networked map that outlines how these dynamics modu-late the progression of allergic diseases through diverse cellular components,aiming to guide mechanistic studies and systematic treatments for these diseases.
