Research progress on regulatory mechanism of AQP4 polarization distribution in glymphatic system
- VernacularTitle:脑类淋巴系统AQP4极化分布的调控机制研究进展
- Author:
Xue-ling LIN
1
;
Ying LI
;
Jia-le REN
;
Yan-jun ZHANG
;
Peng-wei ZHUANG
;
Qing-sheng YIN
Author Information
- Publication Type:Journal Article
- Keywords: glymphatic system; astrocytes; AQP4; polarization distribution; dystrophin-glycoprotein complex; basement mem-brane
- From: Chinese Pharmacological Bulletin 2025;41(5):811-815
- CountryChina
- Language:Chinese
- Abstract: The glymphatic system(GS)is a unique toxic sub-stance clearance system in brain,which is very important for maintaining the microenvironment stability of the central nervous system.The polarization distribution of aquaporin 4(AQP4)lo-cated in the terminal foot of astrocytes affects the function of GS and participates in the pathological progress of many neurodegen-erative diseases,but the detailed regulation mechanism of AQP4 polarization distribution has not been systematically summarized.Therefore,this paper systematically combs the mechanism of reg-ulating the polarization distribution of AQP4 from the perspective of the composition integrity of dystrophin-glycoprotein complex(DGC)and basement membrane foot complex,and summarizes the potential drug and non-drug therapies for targeted regulation of AQP4 polarization distribution at present,aiming at providing new target reference and theoretical basis for targeted regulation of AQP4 polarization to prevent and treat neurodegenerative dis-eases.
