Spectrum of pathogens in the pus of anal fistula patients in Zhoushan offshore areas and analysis of antibiotic resistance features
10.3760/cma.j.issn.1009-6906.2015.04.006
- VernacularTitle:舟山海岛地区肛瘘患者脓液中的病原菌谱及其耐药特点分析
- Author:
Xiangtao LIN
1
;
Yongjie WANG
;
Guohua HUA
;
Kaiyu ZHOU
;
Jihang ZHOU
Author Information
1. 舟山医院肛肠外科,浙江省舟山,316000
- Publication Type:Journal Article
- Keywords:
Anal fistula;
Pathogen;
E.coli;
Drug resistance
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2015;22(4):267-270
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the spectrum of pathogens in the pus of anal fistula patients in Zhoushan offshore areas and features of antibiotic resistance of pathogens.Methods The spectrum of pathogens in the pus of 132 anal fistula patients admitted into the Zhoushan Hospital from January 2010 to June 2014 and drug sensitivity were analyzed retrospectively.Then,statistical analyses were made in the spectrum of pathogens and drug sensitivity results by using chi-square test and Logistic regression.Results Pathogenic detection in the pus of 132 anal fistula patients revealed that 69 eases were positive,with a positive rate of 52.27％ (69/132),of which 2 cases were mixed infection.From the isolated bacteria,it was indicated that E.coli accounted for 64.79％ (46/71),of which 19 strains of ESBLs-producing E.coli accounted for 41.30％ (19/46).There were 5 strains of enterobaeter cloacae and klebsiella pneumonia,which accounted for 7.04％ (5/71).E.coli was relatively more sensitive to meropenem,amikacin,imipenem and piperacillintazobactam,with drug resistance rates lower than 10％.But,E.coli was less sensitive to other drugs with drug resistance rates higher than 28％.The drug resistance rates of ESBLs-producing E.coli to such non-β-lactam antibiotics as tetracycline,piperacillin-tazobactam,chloromycetin,ciprofloxacin and levofloxacin were relatively higher than those of the non-ESBLs-producing E.coli,with statistical significance (P ＜ 0.05).Conclusions Pathologic detection in the pus of anal fistula patients revealed that E.coli was the prevalent bacteria,with ESBLs-producing E.coli accounting for a relatively high rate,and drug resistance rates to various antibiotics were obviously higher than those of the non-ESBLs-producing E.coli,to which greater attention should be paid.
