Research progress of adeno-associated virus in autoimmune diseases
10.3969/j.issn.1000-484X.2025.05.036
- VernacularTitle:腺相关病毒在自身免疫性疾病中的研究进展
- Author:
Weilin HUANG
1
;
Wenwei SHAO
1
Author Information
1. 天津大学医学工程与转化医学研究院,天津 300072
- Publication Type:Journal Article
- Keywords:
Adeno-associated virus;
Organ-specific autoimmune diseases;
Systemic autoimmune diseases
- From:
Chinese Journal of Immunology
2025;41(5):1232-1237
- CountryChina
- Language:Chinese
-
Abstract:
Adeno-associated virus(AAV)is a small virus that relies on other helper viruses to replicate.In recent years,with the rapid development of gene therapy,AAV has been widely used as a vector for gene therapy due to its low immunogenicity and wide host range.Many studies have shown that AAV in a variety of autoimmune diseases in animal models showed promising therapeutic effect,such as multiple sclerosis,type 1 diabetes,rheumatoid arthritis,etc,it was proved that AAV gene therapy can slow down the disease progression and reduce its severity.Transmission of autoimmune disease-related genes through AAV may become a new strategy to treat autoimmune diseases.This review will discuss the application and efficacy of AAV in autoimmune diseases based on the latest research progress.
