The expression and significance of bone morphogenetic protein-4 in the patients with simple obesity in coastal areas
10.3760/cma.j.issn.1009-6906.2016.02.015
- VernacularTitle:沿海地区单纯性肥胖患者骨成型蛋白-4的表达及意义
- Author:
Jianxia SHI
1
;
Qin HUANG
1
Author Information
1. 第二军医大学附属长海医院内分泌科, 上海,200433
- Publication Type:Journal Article
- Keywords:
Simple obesity;
Bone morphogenetic protein-4;
Insulin resistance
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2016;23(2):141-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression levels of bone morphogenetic protein (BMP-4) in the people with simple obesity in coastal areas and its relationship with the BMP-4 expression,body mass index (BMI),waist hip ratio (WHR),fasting blood glucose (FBG),fasting insulin (FINS) and HOMA-IR.Plasma BMP-4 levels of 40 cases with simple obesity and the controls were respectively detected by ELISA.And then,the association of BMP-4 levels with BMI,WHR,HOMA-IR,blood lipids,HbA1c,FBG,FINS and HOMAIR were analyzed by Logistic regression.Methods The BMP-4 levels in the patients with simple obesity (10.98 ±6.76) were significantly higher than those of the control group (5.12 ±3.01),with statistical significance (P ＜ 0.01).Logistic regression analysis indicated that the BMP-4 levels were positively correlated with the levels of triglyceride(TG),BMI,FINS and HOMA-IR,with the r value being respectively 0.421,0.425,0.473 and 0.396 (P ＜ 0.01).Multiple regression analysis was made with BMP-4 as the function,sex,age,WHR,BMI,TG,total cholesterol (TC),low density lipid (LDL),high density lipid (HDL),HbA1c,FBG,FINS and BMP-4 as the independent variables.Results indicated that the FINS level was a related factor affecting the BMP-4 level.Binomial Logistic regression analysis indicated that the BMP-4 level was still significantly correlated with simple obesity,following tight control of such factors as sex,age,WHR,TG,TC,LDL,HDL,HbA1c,FBG and FINS.Conclusions The changes in the BMP-4 levels were associated with metabolism disorder of the patients with simple obesity,which might be involved in the pathogenesis of simple obesity.
