Advances in DNA methylation of brain-derived neurotrophic factor and depression
- VernacularTitle:脑源性神经营养因子DNA甲基化与抑郁
- Author:
Zi-yun LIAO
1
;
Meng-yu WANG
;
Jing-yi QIAO
;
Run ZHANG
;
Pei-dong LIU
;
Xin-wang CHEN
Author Information
- Publication Type:Journal Article
- Keywords: brain-derived neurotrophic factor; DNA methyla-tion; genetic structure; depression; promoter; exon
- From: Chinese Pharmacological Bulletin 2025;41(5):825-829
- CountryChina
- Language:Chinese
- Abstract: Depression is a heterogeneous mental disorder in which the interaction between genetic susceptibility and environ-mental factors plays a key role in its pathogenesis.Although the specific mechanisms of the disease still need to be thoroughly studied and elucidated,there is now a broad consensus that epi-genetic markers have a central influence on its mechanism of ac-tion.DNA methylation of brain-derived neurotrophic factor(BD-NF)is not only regarded as a promising epigenetic biomarker of pathology,but may also help predict the efficacy of antidepres-sants.In this paper we reviewed the gene structure of BDNF and its DNA methylation regulation mechanism,and also analyzed the changes of DNA methylation of this factor in depression pa-tients and animal models,aiming to provide new ideas and theo-retical support for clinical research.
