Research progress on the role of exosomal microRNAs in methamphetamine-induced neurotoxicity and drug development

VernacularTitle:外泌体miRNAs在甲基苯丙胺诱导的神经毒性及戒断药物研发中的研究进展
Author: Ying ZHOU ¹ ; Wei SUN ; Genmeng YANG ; Wenjuan DONG ; Rui DAI ; Shijun HONG ; Lihua LI
Author Information

1. 昆明医科大学科研实验中心电子显微镜实验室,昆明 650500;昆明医科大学法医学院,国家卫生健康委员会毒品依赖和戒治重点实验室,昆明 650500
Publication Type:Journal Article
Keywords: methamphetamine; exosome miRNA; neurotoxicity; drug therapy
From: Chinese Journal of Comparative Medicine 2024;34(12):117-126
CountryChina
Language:Chinese
Abstract: Methamphetamine(METH)is a new type of abused drug with a strong central stimulant effect.Its excitatory pathway involves a series of central higher-level functions,including drug-related rewards and motivation,learning and memory,decision-making,and execution.METH not only causes neurotoxicity,but its long-term use may also cause cognitive dysfunction,loss of personality,and may lead to serious social violence in addicts.Exosomes,as a novel cell-to-cell carrier,are involved in the occurrence and development of drug addiction,and exosome microRNAs are important biomarkers for METH addiction and are also involved in various aspects of METH-induced neurotoxicity.Eoxosmes may thus be useful therapeutic carriers providing a new approach for the diagnosis and treatment of METH abuse.