Changes in hepatic microcirculation perfusion after acute carbon monoxide poisoning and effects of hyperbaric oxygen in rats
10.3760/cma.j.issn.1009-6906.2017.01.007
- VernacularTitle:急性一氧化碳中毒大鼠肝脏微循环灌注变化及高压氧暴露的影响
- Author:
Cong WANG
1
;
Chunjin GAO
;
Fang LIANG
;
Lina MA
;
Zhuo LI
;
Jing YANG
Author Information
1. 首都医科大学附属北京朝阳医院高压氧科, 北京,100020
- Publication Type:Journal Article
- Keywords:
Acute carbon monoxide poisoning;
Hyperbaric oxygen;
Hepatic;
Microcirculation;
Laser Doppler blood perfusion imager
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2017;24(1):28-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe changes in hepatic microcirculation perfusion after acute carbon monoxide poisoning and effects of hyperbaric oxygen (HBO) on hepatic microcirculation by using laser Doppler blood perfusion imager.Methods Ninety Wistar rats were randomly divided into 9 groups:the control group,the CO exposure group which was subdivided into the CO exposure day 1,3,7 and 12 groups (or the CO day 1 group,the CO day 3 group,the CO day 7 group and the CO day 12 group),the CO exposure + HBO group which was subdivided into CO exposure + HBO therapy day 1,3,7 and 12 groups (or the HBO day 1 group,HBO day 3 group,HBO day 7 group and HBO day 12 group).Levels of hepatic and intestinal mucosa microcirculation perfusion were detected by using laser blood perfusion imager.Results In the control group,the CO day 1 group and the HBO day 1 group,the level of hepatic microcirculation perfusion was significantly lower than that of intestinal mucosa microcirculation perfusion.Statistical significance could be seen when comparisons were made between them (P ＜ 0.05),however,changes of the two were identical.The level of hepatic microcirculation perfusion in the CO day 1 group was obviously increased,as compared with those of the HBO day 1,3,7 and 12 groups(P ＜0.05).However,there was no statistical significance when comparisons were made between the CO day 12 group and the HBO day 12 group(P ＞ 0.05).Conclusions Laser Doppler blood perfusion imager could detect changes in the level of hepatic microcirculation perfusion.Acute carbon monoxide poisoning could obviously decrease the level of hepatic microcirculation perfusion,but HBO treatment could help to improve hepatic microcirculation disturbance.
