A bidirectional two-sample Mendelian randomization study on causal relationship between major depression disorder,anxiety disorders and cancers
10.3969/j.issn.1000-6729.2025.11.01
- VernacularTitle:抑郁症和焦虑症与癌症因果关系的双向双样本孟德尔随机化研究
- Author:
Yuliang ZHANG
1
;
Ming ZHANG
1
;
Long YANG
1
;
Zirong LIU
1
;
Rui FENG
1
;
Chunqiang LI
1
;
Zilin CUI
1
Author Information
1. 天津市第一中心医院,天津 300392
- Publication Type:Journal Article
- Keywords:
Mendelian randomization;
single nucleotide polymorphism;
major depressive disorder;
anxiety;
cancer
- From:
Chinese Mental Health Journal
2025;39(11):929-936
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the potential causal relationships between major depressive disorder(MDD),anxiety disorder(AD)and various highly prevalent cancers from the genetic perspective.Methods:Sum-mary statistics from large-scale genome-wide association studies(GW AS)were analyzed using a bidirectional two-sample Mendelian randomization(MR)approach.The inverse variance weighting method(IVW)was usedas the main analytical approach.The intercept term of MR-Egger regression and the MR-PRESSO method were adopted for the pleiotropy test.Results:The IVW analysis revealed potential causal relationships between MDD and breast cancer[OR(95％CI):1.11(1.01-1.22),P＜0.05],AD and lung cancer[OR(95％CI):1.30(1.02-1.65),P＜0.05],and between colon cancer and MDD[OR(95％CI):1.05(1.00-1.11),P＜0.05].The results of the pleiotropy test showed that the intercept terms of the MR-Egger regression were not statistically significant,indica-ting the absence of pleiotropy.The MR-PRESSO method detected outliers only in the relationship between MDD and breast cancer.The association between MDD and breast cancer remained significant after correction for outliers[OR(95％CI):1.10(1.03-1.17),P＜0.05].Conclusion:The study suggests that MDD may be a risk factor for breast cancer,AD may increase the risk factor for lung cancer,and colon cancer may elevate the risk factor of MDD.Moreover,the possibility of reverse causal relationships has been excluded in all these cases.
