Research progress on the mechanism of IL-33/ST2 signaling pathway in kidney diseases
10.12092/j.issn.1009-2501.2025.08.014
- VernacularTitle:IL-33/ST2信号通路在肾脏疾病中作用机制的研究进展
- Author:
Qian WANG
1
;
Changchang LIANG
1
;
Shipeng SHEN
1
;
Maodong LIU
1
;
Lu BAI
1
Author Information
1. 河北医科大学第三医院肾内科;河北省糖尿病肾脏疾病重点实验室;河北省肾脏病研究中心;石家庄 050011,河北
- Publication Type:Journal Article
- Keywords:
interleukin-33;
ST2;
immune regula-tion;
inflammation;
kidney diseases
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(8):1122-1126
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-33(IL-33)is a member of the interleukin-1 superfamily and a"warning fac-tor"for inflammation in the body.When cells die or tissues are damaged,IL-33 is released in large quantities and binds to its receptor ST2 to form a complex,exerting various biological effects.IL-33/ST2 signaling pathway is activated in many kidney diseases,such as acute renal injury,obstructive ne-phropathy,diabetes nephropathy,IgA nephropathy,lupus nephritis,and kidney transplantation.It plays an important role in inflammation and renal fibro-sis by regulating the intrinsic and adaptive immune responses of the kidney.This article reviews the re-search progress of IL-33/ST2 signaling in common kidney diseases,hoping to provide new targets and ideas for the treatment of kidney diseases.
