Tirzepatide in chronic weight management: From mechanism to clinical application

VernacularTitle:从机制到临床探索替尔泊肽在长期体重管理中的应用
Author: Yingying LUO ¹ ; Ziwei LIN ; Linong JI
Author Information

1. 北京大学人民医院内分泌科，北京　100044
Publication Type:Journal Article
Keywords: Tirzepatide; GIP/GLP-1 receptor agonist; Obesity; Weight loss; Weight management
From: Chinese Journal of Endocrinology and Metabolism 2025;41(7):596-600
CountryChina
Language:Chinese
Abstract: Obesity is a common chronic disease associated with an increased risk of multiple comorbidities and premature mortality. Tirzepatide, a glucose-dependent insulinotropic polypeptide (GIP)/glucagon-like peptide 1 (GLP-1) receptor agonist, has demonstrated significant efficacy in multiple studies in reducing body weight and fat mass, improving body composition and metabolic parameters, lowering the risk of obesity-related complications and improving health and quality of life. This review summarizes the underlying mechanisms of tirzepatide and recent advances in its clinical research, providing a reference for clinical practice.