The abnormalities of amplitude of low-frequency fluctuation in the resting-state functional magnetic resonance imaging of first-episode medication-na(i)ve schizophrenia before and after antipsychotic drugs therapy
10.3760/cma.j.issn.1006-7884.2017.02.009
- VernacularTitle:精神分裂症首次发病未用药患者药物治疗前后静息态脑功能低频振幅的变化特征
- Author:
Feng CHEN
1
;
Qiankun YAO
;
Dafei ZHAN
;
Mengjie PAN
;
Xinxin XIE
;
Changqing LI
;
Zengbao XING
;
Jianjun LI
Author Information
1. 海南省人民医院放射科,海口,570311
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Magnetic resonance imaging;
Resting-state;
Amplitude of low frequency fluctuation
- From:
Chinese Journal of Psychiatry
2017;50(2):133-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the abnormalities of amplitude of low-frequency fluctuation (ALFF) in the resting-state functional magnetic resonance imaging (rs-fMRI) of first-episode medication-naive schizophrenia before and after antipsychotic drugs therapy,the correlation between brain activity and clinical syndromes was to be analyzed.Methods This prospective study was approved by the local ethical conmnittee,and written informed consent was obtained from all participants.21 antipsychotic-naive first-episode patients with schizophrenia and 25 healthy individuals were recruited and underwent resting-state functional MR imaging.The patients were re-scanned at the end of 3 months after the antipsychotic treatment.The differences of ALFF between patients and controls were analyzed with two-sample t test,the differences of ALFF in patients before and after antipsychotic drugs therapy were analyzed with two-sample t test.Results (1) The scores of Global Assessment of Functioning Scale,PANSS total score,PANSS positive score,PANSS negative score and PANSS general psychopathology score were significantly improved after antipsychotic drugs therapy (t=6.45,5.13,3.98,3.29,4.32;P＜0.01).(2) Compared with the healthy controls,resting-state ALFF in schizophrenia patients significantly decreased in left paracentral lobule(PCL),left superior occipital gyrus(SOG)/bilateral calcarine/cuneus,middle occipital gyrus(MOG),and right insula (uncorrected,t=-4.91,-4.30,-4.18,-3.59;P＜0.01,cluster voxels＞10),resting-state ALFF in schizophrenia patients significantly increased in anterior cingulate cortex (ACC) and right lentiform nucleus (uncorrected,t=3.60,3.44;P＜0.01,cluster voxels＞10).(3) After antipsychotic drugs therapy for 3 months,the ALFF values increased in bilateral cuneus and decreased in left ACC compared with baseline(uncorrected,t=3.91,-4.42;P＜0.01,cluster voxels＞10).(4) The ALFF values in the anterior cingulate cortex(ACC) at baseline were positively correlated with negative symptoms scores of PANSS (r=0.594,P=0.005).The ALFF values in the left MOG at baseline were negatively correlated with total scores of PANSS (r=-0.464,P=0.034).Conclusions This study provides evidence for resting state brain activity abnormalities of some brain regions in patients with schizophrenia.ACC and occipital gyrus are the key brain regions and may be responsible for certain schizophrenic symptoms,which could contribute to explore the neuropharmacology mechanisms of schizophrenia.
