Prevention and treatment strategies for reproductive toxicity of Tripterygium wilfordii multiglucoside in children based on the"kidney essence-tian gui"
10.3969/j.issn.1006-2157.2025.07.009
- VernacularTitle:从"肾精-天癸"探讨雷公藤多苷所致儿童生殖毒性的中医药防治思路
- Author:
Jixiang XU
1
;
Xia ZHANG
1
;
Jiaxian LIU
1
;
Ruiyun BAO
1
;
Chundong SONG
1
;
Xianqing REN
1
;
Ying DING
1
Author Information
1. 河南中医药大学第一附属医院 郑州 450003;河南中医药大学儿科医学院
- Publication Type:Journal Article
- Keywords:
Tripterygium wilfordii;
reproductive toxicity;
children;
kidney essence;
tian gui
- From:
Journal of Beijing University of Traditional Chinese Medicine
2025;48(7):954-959
- CountryChina
- Language:Chinese
-
Abstract:
Tripterygium wilfordii multiglucoside,the primary active constituent of the Chinese materia medica of Tripterygium wilfordii,has anti-inflammatory and immune-regulation properties and is widely used to treat kidney and rheumatic and immunological diseases.However,the potential adverse effects of Tripterygium wilfordii multiglucoside on pediatric gonadal development have limited its clinical application in pediatrics.According to the traditional Chinese medicine theory,the reproductive toxicity of Tripterygium wilfordii is closely associated with deficiency in kidney essence and tian gui disorder.Based on the"kidney essence-tian gui"theory,this study elucidates the transformation of"kidney essence to tian gui"through the qi transformation of"original noumenon to supreme ultimate,"which is synergistically regulated by the accumulation of kidney qi,consolidation of spleen qi,and conveyance and dispersion of liver qi.It is channeled through the interconnected pathways of the thoroughfare channel,conception channel,and governor channel.The physiological process of"kidney essence to tian gui"is damaged by the bitter,cold,and toxicity of Tripterygium wilfordii,leading to kidney asthenia,spleen deficiency,liver depression,and meridian stagnation,causing tian gui dysregulation.Therefore,this study offers traditional Chinese medicine prevention and treatment strategies for pediatric medication safety,including nourishing the kidney essence to replenish the tian gui source,enhancing the middle jiao to strengthen the tian gui guard,regulating liver qi to promote the operation of tian gui,and unblocking the thoroughfare channel,conception channel,and governor channel to ensure the unobstructed pathway of tian gui.
